Androgen Replacement Therapy; Primarily Used to Treat Low Testosterone (T) Levels

 

Androgen Replacement Therapy

Androgen replacement therapy (ART), also known as hormone replacement therapy (HRT) or testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens are replaced. It involves the administration of testosterone through subcutaneous pellets, gels, patches, skin creams, or injections. It is a promising technology that helps improve symptoms of hypogonadism and to raise testosterone level. Hypogonadism means diminished functional activity of the gonads that may result in diminished production of sex hormones.

Primary hypogonadism is caused due to radiation treatment, orchitis, testicular trauma, genetic abnormalities, or chemotherapy, whereas secondary hypogonadism is caused due to genetic abnormalities of hypothalamus and pituitary gland. Androgen replacement therapy aims is to reduce the levels of male hormones, called androgens, in the body, or to stop them from fueling prostate cancer cells. ART blocks male hormone receptors and can suppress the testosterone production. Systemic estrogen therapy is one of the most effective treatment for the relief of troublesome menopausal hot flashes and night sweats.

Clinical hypogonadism is the only FDA-approved (the U.S. Food and Drug Administration) indication for androgen replacement therapy in men. However, it is not approved to treat age-related low testosterone. This type of treatment is prescribed for men who have low naturally produced testosterone levels because of various factors, such as age, disease, or excessive weight loss. Moreover, men who are undergoing treatments for low sex drive should be aware of the risk of side effects, and the benefits of testosterone replacement therapy.

Some men with unnaturally low levels of testosterone can benefit from hormone therapy. It's a good age to start treatment as the decline is only just beginning. Androgen replacement therapy is evolving as a potential treatment option for various other conditions related to testosterone loss, such as sarcopenia, osteoporosis, and even psychological symptoms.


Location: India

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