Gynecological Cancer Drugs Witnessing Launch of Biosimilars as Cost Effective Alternatives for Cancer Treatment

 

Gynecological Cancer Drugs

Gynecologic cancer is any cancer that affects a woman's reproductive organs such as cervical, ovarian, uterine, vaginal, and vulvar. It is one of the leading causes of death among women. According to the American Cancer Society, about 13,800 new cases of invasive cervical cancer are expected to be diagnosed in the U.S. in 2020 and the disease is expected to lead to death of 4,290 women in the same year.

Avastin (Bevacizumab), Bevacizumab, Bleomycin Sulfate, Hycamtin (Topotecan Hydrochloride), Keytruda (Pembrolizumab), Mvasi (Bevacizumab), Pembrolizumab, and Topotecan Hydrochloride are some of the widely used gynecological cancer drugs. Bevacizumab, sold under the brand name is used for the treatment of colorectal, lung, glioblastoma, kidney, cervical, and ovarian cancer. It is approved to treat metastatic colorectal cancer (mCRC) for first- or second-line treatment in combination with intravenous fluorouracil–based chemotherapy.

Bevacizumab, another of the gynecological cancer drugs sold under the brand name Avastin, is given intravenously for the treatment of colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. Various market players are focused on developing biosimilars to Bevacizumab. In March 2021, the European Medicines Agency’s Committee for Medicinal Products for Human Use adopted a positive opinion recommending the marketing authorization of Bevacizumab, a biosimilar co-developed by Biocon Biologics Ltd., a subsidiary of Biocon Ltd., with Viatris, Inc., the U.S.-based healthcare company formed through the merger of Mylan and Upjohn.

Bleomycin Sulfate, sold under the brand name Blenoxane, is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus. It is used in the treatment of squamous cell cancers, melanoma, sarcoma, testicular and ovarian cancer, Hodgkin's, and non-Hodgkin's lymphoma. Use of Bleomycin sulfate may lead to side effects such as fever and chills, adverse skin reactions, nail thickening, nail banding, and hair loss.


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